Wetenschappelijke artikelen

Internationale publicatielijst


Boers SN and Bredenoord AL (2018) Consent for governance in the ethical use of organoids. Nature Cell Biology 20(6):642-645

Rivron N, Pera M, Rossant J, Martinez Arias A, Zernicka-Goetz M, Fu J, van den Brink S, Bredenoord A, Dondorp W, de Wert G, Hyun I, Munsie M, Isasi R (2018) Debate ethics of embryo models from stem cells. Nature 564(7735):183-185

Boers SN, Van Delden JJM, Bredenoord AL (2018) Organoids as Hybrids: ethical implications for the exchange of human tissues. Journal of Medical Ethics 45(2):131-139

Boers SN, de Winter-de Groot KM, Gulmans V, Noordhoek J, van der Ent CK, van Delden JJM, Bredenoord AL (2018) Mini organs in a dish: perspectives of adult Cystic Fibrosis (CF) patients and parents of young CF patients on organoid technology. Journal of Cystic Fibrosis 17(3):407-415

de Windt TS, Niemansburg SL, Vonk LA, van Delden JM, Roes KCB, Dhert WJA, Saris DBF, Bredenoord AL (2019) Ethics in musculoskeletal regenerative medicine; guidance in choosing the appropriate comparator in clinical trials. Osteoarthritis and Cartilage 27(1):34-40

van Dijke I, Bosch L, Bredenoord AL, Cornel M, Repping S, Hendriks S (2018) The ethics of clinical applications of germline genome modification: a systematic review of reasons. Human Reproduction 33(9):1777-1796

Bijlsma RM, Wouters RHP, Wessels H, May AM, Ausems MGEM, Voest EE, Bredenoord AL (2018) Managing unsolicited findings in the genomics area: a qualitative interview study with cancer patients. Psycho-Oncology 27(4):1327-1333

Wouters RHP, Bijlsma RM, Frederix GWJ, Ausems MGEM, van Delden JJM, Voest EE, Bredenoord AL (2018) Is it our duty to hunt for pathogenic mutations? Trends in Molecular Medicine 1:3-6

Kool E, Bos AME, Graaf van der R, Fauser B, Bredenoord AL. Ethics of oocyte banking for third-party assisted reproduction. Human Reproduction Update, in press

Boeckhout M, Zielhuis GA, Bredenoord AL. The FAIR Guiding Principles for Data Stewardship: fair enough? European Journal of Human Genetics, in press

Mostert M, Bredenoord AL, Van Der Sloot B, Van Delden JJM (2018) From privacy to data protection in the EU: implications for Big Data health research. European Journal of Health Law 25:43-55

Bijlsma RM, Wessels H, May AM, Ausems MGEM, Voest EE, Bredenoord AL (2018) Cancer patients’ intentions towards receiving unsolicited genetic information obtained by Next Generation Sequencing. Familial Cancer 17(2):309-316

Jongsma KR and Bredenoord AL (2018) Geometry of trust: why we need to distinguish between horizontal and vertical trust. American Journal of Bioethics 18(4):48-50

Jongsma K, Bredenoord AL, Lucivero F (2018) Digital medicine: an opportunity to revisit the role of bioethicists. American Journal of Bioethics 18(9):69-70

Yarborough M, Bredenoord AL, Joyce N, Kimmelman J, Ogbogu U, Sena ES, Strech D, D’Abramo F, Dirnagl U. Ethical ties between pre-clinical researchers in translational neuroscience and patients in clinical trials. Plos Biology, in press

Mostert M, Koomen BM, Van Delden JJM, Bredenoord AL (2018) Privacy in Big Data Psychiatric and Behavioural Research: a Multiple-Case Study. International Journal of Law and Psychiatry 60:40-44

Appleby JB and Bredenoord AL. Should the 14 day rule for embryo research become the 28 day rule? EMBO Reports, in press

Hendriks S, Giesbertz NAA, Bredenoord AL, Repping S. The Dutch general public’s reasons in favour of and against genome modification. Human Reproduction Open, in press

Vos S, van Diest PJ, Ausems MGEM, van Dijk MR, de Leng WWJ, Bredenoord AL (2018) Ethical considerations for modern molecular pathology. Journal of Pathology 246(4):405-414

Boeckhout M, Scheltens P, Manders P, Smit C, Bredenoord AL, Zielhuis GA. Patients To Learn From: On the Need for Systematic Integration of Research and Care in Academic Health Care. Journal of Clinical and Translational Research, in press


Bredenoord AL, Clevers J, Knoblich J (2017) Human tissues in a dish: the research and ethical implications of organoid technology. Science 355(6322)

Bredenoord AL and Appleby JB (2017) Mitochondrial replacement techniques: remaining ethical challenges. Cell Stem Cell 21(3):301-304

Bredenoord AL and Hyun I (2017) Ethics of stem-cell derived gametes made in a dish: fertility for everyone? EMBO Molecular Medicine 4:396-398

Wouters R, Cornelis C, Newson AJ, Bunnik EM, Bredenoord AL (2017) Scanning the body, sequencing the genome: dealing with unsolicited findings. Bioethics 31(9):648-656

Cote DJ, Bredenoord AL, Smith TR, Ammirati M, Brennum J, Mendez I, Ammar AS, Balak N, Bolles G, Esene IN, Mathiesen T, Broekman ML (2017) Ethical clinical translation of stem cell interventions for neurological disease. Neurology 88(3):322-328

Bredenoord AL & Boeckhout M (2017) Ancillary care obligations for social media platforms. American Journal of Bioethics 3:29-31

Vos S, Van Delden JJM, Van Diest PJ, Bredenoord AL (2017) Moral duties of genomics researchers: why personalized medicine requires a collective approach. Trends in Genetics 33(2):118-128

Habets MGJL, Van Delden JJM, Bredenoord AL (2017) The unique status of first-in-human studies: strengthening the social value requirement. Drug Discovery Today 22(2):471-475

Muskens IS, Diederen SJH, Senders JT, Zamanipoor Najafabadi AH, van Furth WR, May AM, Smith TR, Bredenoord AL, Broekman MLD (2017) Innovation in neurosurgery: less than IDEAL? A systematic review. Acta Neurochirurgica 159(10):1957-1966

Bakker MR, Maas J, Bekker MH, Bredenoord AL, Fauser BC, Bos AM (2017) Autonomy and self-esteem of women who donate to an oocyte cryopreservation bank in The Netherlands. Reprod Biomed Online 35(2):225-231


Habets MGJL, Van Delden JJM, Niemansburg SL, Atkins HL, Bredenoord AL (2016) One-size-fits-all? Ethical considerations for examining efficacy in first-in-human pluripotent stem cell studies. Molecular Therapy 24(12):2039-2042

Giesbertz NAA, Melham K, Kaye J, Van Delden JJM, Bredenoord AL (2016) Personalized Assent for Pediatric Biobanks. BMC Med Ethics 17(1):59

Wouters R, Bijlsma RM, Ausems MGEM, Voest EE, Van Delden JJM, Bredenoord AL (2016) Am I my family’s keeper? Disclosure dilemma’s in next generation DNA sequencing. Human Mutation 37(12):1257-1262

Otto IA, Breugem CC, Malda J, Bredenoord AL (2016) Ethical considerations in the translation of regenerative biofabrication technologies into clinic and society. Biofabrication 8(4):042001

Cornelis C, Tibben A, Dondorp W, van Haelst M, Bredenoord AL, Knoers N, Duwell M, Bolt I, van Summeren M (2016) Whole exome sequencing in pediatrics: Parents’ considerations toward return of unsolicited findings for their child. European Journal of Human Genetics 24(12):1681-1687

Broekman ML, Carriere M, Bredenoord AL (2016) Surgical innovation: the ethical agenda. Medicine 95(25):e3790

Boers SL, Van Delden JJM, Clevers H, Bredenoord AL (2016) Organoid biobanking: identifying the ethics. EMBO reports pii: e201642613

Broekman ML, Carriere M, Bredenoord AL (2016) Surgical innovation: the ethical agenda. Medicine 95(25):e3790

Daley GQ, Hyun I, Apperley J, Barker R, Benvenisty N, Bredenoord AL, Breuer C, Caulfield T, Cedars M, Frey-Vasconcells J, Heslop H, Jin Y, Lee RT, McCabe C, Munsie M, Murry C, Piantadosi S, Rao M, Sipp DA, Studer L, Sugarman J, Takahashi M, Zimmerman M, Kimmelman J (2016) Setting global standards for stem cell research and clinical translation: the 2016 ISSCR Guidelines. Stem Cell Reports 6(6):787-97

Bijlsma RM, Bredenoord AL, Gadella-Hooijdonk CG, Lolkema MPJ, Sleijfer S, Voest EE, Ausems MGEM, Steeghs N (2016) Unsolicited findings of Next Generation Sequencing for tumor analysis within a Dutch consortium: Clinical daily practice reconsidered. European Journal of Human Genetics 24(10):1496-500

Giesbertz NAA, Bredenoord AL, Van Delden JJM. When children become adults: should biobanks re-contact? PloS Medicine 13(2):e1001959

MGJL Habets, Van Delden JJM, Bredenoord AL (2016) Studying the lay of the land: views and experiences of professionals in the translational pluripotent stem cell field. Regenerative Medicine 11(1):63-71

Mostert M, Bredenoord AL, Biesaart M, Van Delden JJM (2016) Big Data in medical research and EU data protection law: challenges to the consent or anonymise approach. European Journal of Human Genetics 24(7):956-60

Veldwijk J, Lambooij MS, Kallenberg FGJ, van Kranen HJ, Bredenoord AL, Dekker E, Smit HA, de Wit GA (2016) Preferences for genetic screening for colectoral cancer within a population-based screening program: a discrete choice experiment. European Journal of Human Genetics 24(3):361-6


Niemansburg SL, Habets MGJL, Van Delden JJM, Bredenoord AL (2015) Participant selection for preventive Regenerative Medicine trials: ethics of including individuals at risk. Journal of Medical Ethics 41(11):914-6

Bredenoord AL, Mostert M, Isasi R, Knoppers BM (2015) Data Sharing in Stem Cell Translational Science: Policy Statement by the International Stem Cell Forum Ethics Working Party. Regenerative Medicine 10(7):857-61

Boers SL, Van Delden JJM, Bredenoord AL (2015) Broad consent is consent for governance. American Journal of Bioethics 15(9):53-5

Giesbertz NAA, Bredenoord AL, Van Delden JJM (2015) Consent procedures in pediatric biobanks. European Journal of Human Genetics 23:1129-1134

Bredenoord AL, Bijlsma R, Van Delden JJM (2015) Next generation DNA sequencing: always allow an opt out. American Journal of Bioethics 15(7):28-30

Bredenoord AL and Hyun I (2015) The road to mitochondrial gene transfer: follow the middle lane. Molecular Therapy 23(6):975-6

Janssen S, Bredenoord AL, Dhert W, Oner C, Verlaan JJ (2015) Potential conflict of interest of editorial board members of five leading spine journals. PloS One 10(6):e0127362

Boers S, Van Delden JJM, Knoers N, Bredenoord AL (2015) Postmortem disclosure of genetic information to family members: active or passive disclosure? Trends Mol Med 21/3:148-153

Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q (2015) CRISPR germline engineering: the community speaks. Nature Biotechnology 33(5):478-486

Bredenoord AL. The Principles of Biomedical Ethics Revisited. In: Ramadan T, Audi J (eds) Principles of Islamic Biomedical Ethics. Bloomsbury Publishing, forthcoming

van Delden JJM and Bredenoord AL. Future challenges for bioethics: regenerative medicine. UNESCO. In: Global Bioethics: what for? 20th anniversary of UNESCO’s Bioethics Program. German Solinis (ed), Paris: UNESCO publishing 2015, pp 137-141

Niemansburg SL, Tempels TH, Dhert WJA, Van Delden JJM, Bredenoord AL (2015) Societal Impacts of Regenerative Medicine: reflection on the views of orthopedic professionals. Regenerative Medicine 10(1):17-24

Niemansburg SL, Van Delden JJM, Dhert WJA, Bredenoord AL (2015) Reconsidering the ethics of sham interventions in an era of emerging technologies. Surgery pii: S0039-6060(14)00786-7

Giesbertz NAA, Bredenoord AL, Van Delden JJM (2015) Consent procedures in pediatric biobanks. European Journal of Human Genetics 23:1129-1134


Mooien WA, Bredenoord AL, Viergever RF, Peul WC (2014) Scientific evaluation of spinal implants; an ethical necessity. Spine 39:2115-2118

Habets MGJL, Van Delden JJM, Bredenoord AL (2014) The Social Value of Clinical Research. BMC Medical Ethics 15(1):66

Niemansburg SL, Teraa M, Hesam H, Van Delden JJM, Verhaar MC, Bredenoord AL (2014) Stem cell trials for vascular medicine: ethical rationale. Tissue Engineering part A, 20(19-20):2567-74

Peul WC, Bredenoord AL, Jacobs WCH (2014) Avoid surgery as first line treatment for non-specific low back pain. British Medical Journal 349:g4214

Bredenoord AL, De Vries MC, Van Delden JJM (2014) The right to an open future concerning genetic information. American Journal of Bioethics 14(3):21-3

Koudstaal S, Niemansburg SL, Dib N, Wallet J, Doevendans PA, Bredenoord AL, Chamuleau SAJ (2014) Placebo in autologous cell-based interventions: hard pill to swallow? Journal of the American College of Cardiology 63(25 Pt A):2877-9

Niemansburg SL, Habets MGJL, Van Delden JJM, Bredenoord AL (2014) Disclosure of risks and uncertainties are especially vital in light of Regenerative Medicine. American Journal of Bioethics 14(4):14-6

Isasi R, Knoppers BM, Andrews PW, Bredenoord AL, Colman A, Hin LE, Hull S, Kim OJ, Lomax G, Morris C, Sipp D, Stacey G, Wahlstrom J, Zeng F; for the International Stem Cell Forum Ethics Working Party (2014) Identifiability and Privacy in Pluripotent Stem Cell Research. Cell Stem Cell 14:427-430

Habets MGJL, Van Delden JJM, Bredenoord AL (2014) The inherent ethical challenge of first-in-human pluripotent stem cell trialsRegenerative Medicine 9(1):1-3

Giesbertz NAA, Bredenoord AL, Van Delden JJM (2014) Reply to Waligora. European Journal of Human Genetics 22:855

Giesbertz NAA, Bredenoord AL, Van Delden JJM (2014) Clarifying assent in pediatric research. European Journal of Human Genetics 22(2):266-9

Knoppers BM, Avard D, Sénécal K, Zawati MH along with the P3G International Paediatrics Platform members Bredenoord AL, Hall A, Hens K, Pinxten W, Wallace S, Parry D, Clayton EW (2014) Return of Whole-Genome Sequencing Results in Paediatric Research. European Journal of Human Genetics 22(1):3-5

Niemansburg SL, Van Delden JJM, Oner FC, Dhert WJA, Bredenoord AL (2014) Ethical implications of regenerative medicine in orthopedics: an empirical study with surgeons and scientists in the field. The Spine Journal 14(6):1029-1035


Lolkema MP, Gadellaa – van Hooijdonk CG, Bredenoord AL, Voest EE (2013) Reply to Battistuzzi et al. Journal of Clinical Oncology 31(32):4165-6

Bredenoord AL, Giesbertz NAA, Van Delden JJM (2013) Consent for medical device registries. Public Health Ethics 6(2):226-229

Bredenoord AL, De Vries MC, Van Delden JJM (2013) Next Generation Sequencing: does the next generation still have a right to an open future? Nature Reviews Genetics 14:306 doi:10.1038/nrg3459

Giesbertz NAA, Bredenoord AL, Van Delden JJM (2013) A thick opt-out is often sufficient. American Journal of Bioethics 13(4):44-46

Lolkema MP, Gadellaa – van Hooijdonk CG, Bredenoord AL, Kapitein P, Roach N, Cuppen E, Knoers NV, Voest EE (2013) Ethical and counselling challenges surrounding the return of genetic results in oncology. Journal of Clinical Oncology 31(15):1842-8

Niemansburg SL, Van Delden JJM, Dhert WJA, Bredenoord AL (2013) Regenerative medicine interventions for orthopedic disorders: ethical issues in the translation into patients. Regenerative Medicine 8(1):65-73


Giesbertz NAA, Bredenoord AL, Van Delden JJM (2012) Inclusion of Residual Tissue in Biobanks: Opt-in or Opt-out? PLoS Biology 10(8): e1001373

Bredenoord AL and Van Delden JJM (2012) Disclosing individual genetic research results to deceased participants’ relatives by means of a qualified disclosure policy. American Journal of Bioethics 12(10):10-12

Isasi R, Knoppers BM, Andrews PW, Bredenoord AL, Colman A, Hin LE, Hull S, Kim OJ, Lomax G, Morris C, Sipp D, Stacey G, Wahlstrom J, Zeng F; for the International Stem Cell Forum Ethics Working Party (2012) Disclosure and management of research findings in stem cell research and banking: policy statement. Regenerative Medicine 7(3):439-448

Van der Baan FH, Bernabe R, Bredenoord AL, Gregoor JG, Meynen G, van Thiel GJMW. Consent in psychiatric biobanks for pharmacogenetic research (2012) International Journal of Neuropsychopharmacology 21:1-6

Bredenoord AL, Lock MTW, Broekmans F (2012) Ethics of intergenerational (father-to-son) sperm donation. Human Reproduction 27(5):1286-1291

Bredenoord AL and Van Delden JJM (2012) Research ethics in genomics research: feedback of individual genetic data to research participants. In: Human Medical Research: Ethical, Economic and Socio-Cultural aspects. Vollmann J, Schildmann J and Sandow V (eds) Basel: Springer pp 127-136


Bredenoord AL, Onland-Moret NC, Van Delden JJM (2011) Feedback of individual genetic results to research participants: in favor of a qualified disclosure policy. Human Mutation 32:1–7

Bredenoord AL, Kroes HY, Cuppen E, Parker M, Van Delden JJM (2011) Disclosure of individual genetic data to research participants: the debate reconsidered. Trends in Genetics 27(2):41-47

Bredenoord AL, Dondorp WJ, Pennings G, De Wert G (2011) Nuclear transfer to prevent mitochondrial DNA disorders: revisiting the debate on reproductive cloning. Reproductive Biomedicine Online 22:200-207

Bredenoord AL, Dondorp WJ, Pennings G, De Wert G (2011) Ethics of modifying the mitochondrial genome. Journal of Medical Ethics 37:97-100


Bredenoord AL and Braude P (2010) Ethics of mitochondrial gene replacement: from bench to bedside. British Medical Journal 341:c6021

Poulton J and Bredenoord AL (2010) 174th ENMC International Workshop: Applying Pre-implantation Genetic Diagnosis to mtDNA Diseases: Implications of Scientific Advances. 19-21 March 2010, Naarden, The Netherlands. Neuromuscular Disorders 20:559-563

Van der Weijden CP, Bredenoord AL, Van Delden JJM (2010) The duty to treat in the context of an influenza pandemic. Vaccine 28:5260-5264

Bredenoord AL, Dondorp WJ, Pennings G, De Wert G (2010) Avoiding transgenerational health risks of mitochondrial DNA disorders: a morally acceptable reason for sex selection? Human Reproduction 25:1354-1360

Bredenoord AL, Van der Graaf R, Van Delden JJM (2010) Towards a “post-posthuman dignity area” in evaluating emerging enhancement technologies. American Journal of Bioethics 10(7):55-57

Bredenoord AL, Krumeich A, De Vries MC, Dondorp WJ, De Wert G (2010) Reproductive decision-making in the context of mitochondrial DNA disorders: experiences of professionals. Clinical Genetics 77(1):10-17


Bredenoord AL, Dondorp WJ, Pennings G, De Die-Smulders CEM, Smeets HJ, De Wert G (2009) Preimplantation genetic diagnosis for mitochondrial DNA disorders. Ethical guidance for clinical practice. European Journal of Human Genetics 17:1550-1559


Bredenoord AL, Pennings G, De Wert G (2008) Ooplasmic transfer and nuclear transfer to prevent mitochondrial DNA disorders: conceptual and normative issues. Human Reproduction Update 14(6):669-678

Bredenoord AL, Dondorp WJ, Pennings G, De Die-Smulders CEM, De Wert G (2008) PGD to reduce reproductive risk: the case of mitochondrial DNA disorders. Human Reproduction 23(11):2392-2401

Bredenoord AL, Pennings G, Smeets HJ, de Wert G (2008) Dealing with uncertainties. Ethics of prenatal diagnosis and preimplantation genetic diagnosis for mitochondrial disorders. Human Reproduction Update 14(1):83-94

Nederlandstalige publicatielijst

Annelien Bredenoord, Morele Vooroordelen. In: M. Geels & T. van Opijnen (red), Waar verzet jij je tegen? Amsterdam: Maven Publishing 2017

Annelien Bredenoord, Medische Ethiek. In: Th. de Graaf (red), Redelijk Radicaal: 50 jaar D66. Amsterdam: Balans, 2016

Annelien Bredenoord, ‘Samen beslissen in de zorg: een sociaal-liberale invulling’. Idee nr 1: Gezondheid:mij ’n zorg! 2016:15-18

Martine de Vries & Annelien Bredenoord (2014) Next Generation Sequencing: heeft de volgende generatie nog recht op een open toekomst? Tijdschrift voor Kindergeneeskunde 82(1):45-48

Annelien Bredenoord, Reproductieve autonomie ontrafeld. Tijdschrift voor Gezondheidszorg en Ethiek 2013; 23(3):84

Annelien Bredenoord, Ethiek van het persoonlijk genoom. Huisarts&Wetenschap, Oktober 2012

Annelien Bredenoord, Zwanger worden van een kind met het Huntington-gen? In: de Ruijter et al (eds) Huisarts tussen individu en familie. Morele dilemma’s in de huisartspraktijk. Assen: Van Gorcum 2012, pp 25-28

Annelien Bredenoord, ‘Kies je kids’? Reproductieve autonomie. Idee (April 2011):21-27

Annelien Bredenoord, Boek review in Tijdschrift voor Gezondheidszorg & Ethiek (2004:3): van der Kwaak et al (eds), “Strategies of preventing female circumcision”, Doetinchem 2003

Annelien Bredenoord, ‘D66 en religie’. Idee (2002) 23:4